Dendritic trafficking faces physiologically critical speed-precision tradeoffs
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چکیده
منابع مشابه
Dendritic trafficking faces physiologically critical 1 speed - precision tradeoffs
12 Nervous system function requires intracellular transport of channels, receptors, mRNAs, and other cargo throughout complex neuronal morphologies. Local signals such as synaptic input can regulate cargo trafficking, motivating the leading conceptual model of neuron-wide transport, sometimes called the “sushi-belt model” (Doyle and Kiebler, 2011). Current theories and experiments are based on ...
متن کاملDendritic trafficking faces physiologically critical speed-precision tradeoffs
Nervous system function requires intracellular transport of channels, receptors, mRNAs, and other cargo throughout complex neuronal morphologies. Local signals such as synaptic input can regulate cargo trafficking, motivating the leading conceptual model of neuron-wide transport, sometimes called the 'sushi-belt model' (Doyle and Kiebler, 2011). Current theories and experiments are based on thi...
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12 Most neurons have complex morphologies with long processes and dynamic, nonuniform spatial expression patterns of subcellular organelles and macromolecules. It is thought that trafficking and delivery of this subcellular cargo depends on purely local signals, rather than a global addressing system. Yet it remains unclear how such a decentralized system performs in complex morphologies. We ma...
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ژورنال
عنوان ژورنال: eLife
سال: 2016
ISSN: 2050-084X
DOI: 10.7554/elife.20556